Standard

Percent mammographic density

near ZNF365 · rs10995181

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 24,192 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.072 lower (95% confidence interval 0.052-0.092); p = 4 × 10⁻¹³.

Where it sits Chromosome 10, band 10q21.2 — between genes, 11.5 kb from LINC02929.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Percent mammographic density compared to the general population.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Percent mammographic density.

T/T Published research associates this genotype with typical/baseline likelihood of Percent mammographic density — no copies of the reported risk allele.

Source

Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

Sieh W, Rothstein JH, Klein RJ, Alexeeff SE, Sakoda LC, Jorgenson E, McBride RB, Graff RE, McGuire V, Achacoso N, Acton L, Liang RY

and 8 more — show all

Lipson JA, Rubin DL, Yaffe MJ, Easton DF, Schaefer C, Risch N, Whittemore AS, Habel LA

Nature communications · 2020 · PMID 33037222 · open access

Questions about rs10995181

What is rs10995181?

rs10995181 is a single position in the genome, in or near the near ZNF365 gene. Published research associates it with percent mammographic density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10995181 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10995181 come from?

GWAS Catalog, Nature communications 2020, PMID:33037222. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Percent mammographic density (rs10995181). MyGeneLog™. https://www.mygenelog.com/variants/rs10995181

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