C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heel bone mineral density compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heel bone mineral density.
T/TPublished research associates this genotype with typical/baseline likelihood of Heel bone mineral density — no copies of the reported risk allele.
Nature genetics · 2019 · PMID 30598549 · open access
Questions about rs10992489
What is rs10992489?
rs10992489 is a single position in the genome, in or near the ZNF484 gene. Published research associates it with heel bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10992489 linked to?
On MyGeneLog this position is linked to Heel Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.
Does having rs10992489 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10992489 come from?
GWAS Catalog, Nat Genet 2018, PMID:30598549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.