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Glucocorticoid-induced osteonecrosis

GRIN3A · rs10989692

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Glucocorticoid-induced osteonecrosis compared to the general population. (GWAS Catalog, Blood 2015, PMID:26265699)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Glucocorticoid-induced osteonecrosis. (GWAS Catalog, Blood 2015, PMID:26265699)

G/G Published research associates this genotype with typical/baseline likelihood of Glucocorticoid-induced osteonecrosis — no copies of the reported risk allele. (GWAS Catalog, Blood 2015, PMID:26265699)

Source: GWAS Catalog, Blood 2015, PMID:26265699

Questions about rs10989692

What is rs10989692?

rs10989692 is a single position in the genome, in or near the GRIN3A gene. Published research associates it with glucocorticoid-induced osteonecrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10989692 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10989692 come from?

GWAS Catalog, Blood 2015, PMID:26265699. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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