A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Osteoarthritis compared to the general population.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Osteoarthritis.
C/CPublished research associates this genotype with typical/baseline likelihood of Osteoarthritis — no copies of the reported risk allele.
Nature genetics · 2019 · PMID 30664745 · open access
Questions about rs10974438
What is rs10974438?
rs10974438 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10974438 linked to?
On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs10974438 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10974438 come from?
GWAS Catalog, Nat Genet 2019, PMID:30664745. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.