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Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event)

near RPS26P2 · rs10969913

Where this position leads

Condition: Prostate Cancer

rs10969913 Condition: Prostate Cancer Prostate Cancer Condition rs10969913 rs10969913 near RPS26P2

What the study found

Who was studied 3,470 European ancestry individuals.

The effect Each copy of the G allele carried 3.92 times the odds of Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event) (95% confidence interval 2.57-6.00); p = 3 × 10−10.

How common The G allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 9, band 9p21.1 — between genes, 34.6 kb from RPS26P2.

What each result means

A/A No copy of the version the research linked to Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy
Kerns SL, Fachal L, Dorling L, Barnett GC, Baran A, Peterson DR, Hollenberg M, Hao K, Narzo AD, Ahsen ME, Pandey G, Bentzen SM
and 28 more — show all
Janelsins M, Elliott RM, Pharoah PDP, Burnet NG, Dearnaley DP, Gulliford SL, Hall E, Sydes MR, Aguado-Barrera ME, Gómez-Caamaño A, Carballo AM, Peleteiro P, Lobato-Busto R, Stock R, Stone NN, Ostrer H, Usmani N, Singhal S, Tsuji H, Imai T, Saito S, Eeles R, DeRuyck K, Parliament M, Dunning AM, Vega A, Rosenstein BS, West CML
Journal of the National Cancer Institute · 2020 · PMID 31095341 · open access

Questions about rs10969913

What is rs10969913?

rs10969913 is a single position in the genome, in or near the near RPS26P2 gene. Published research associates it with toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10969913 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs10969913 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10969913 come from?

GWAS Catalog, Journal of the National Cancer Institute 2020, PMID:31095341. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event) (rs10969913). MyGeneLog™. https://www.mygenelog.com/variants/rs10969913

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