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Childhood body mass index

near LINGO2 · rs10968118

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−10, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 441,761 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0135 lower (95% confidence interval 0.0094-0.0176); p = 1 × 10−10.

Where it sits Chromosome 9, band 9p21.2 — between genes, 134.6 kb from LINGO2.

What each result means

A/A Two copies of the version the research linked to Childhood body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Childhood body mass index. That is a smaller link than two copies.
G/G No copy of the version the research linked to Childhood body mass index. This is the starting point the study compared everyone against.
Source
Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood
Hawkes G, Beaumont RN, Tyrrell J, Power GM, Wood A, Laakso M, Fernandes Silva L, Boehnke M, Yin X, Richardson TG, Smith GD, Frayling TM
Diabetologia · 2023 · PMID 37280435 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Childhood body mass index (rs10968118). MyGeneLog™. https://www.mygenelog.com/variants/rs10968118

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