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Intracranial aneurysm

SOX17 · rs10958409

Where this position leads

Condition: Intracranial Aneurysm

rs10958409 Condition: Intracranial Aneurysm Intracranial Aneurysm Condition rs10958409 rs10958409 SOX17

What the study found

Who was studied 1,580 European ancestry cases, 6,276 European ancestry controls; replicated in 495 Japanese ancestry cases, 676 Japanese ancestry controls.

The effect Each copy of the A allele carried 1.36 times the odds of Intracranial aneurysm (95% confidence interval 1.24-1.49); p = 1 × 10−10.

How common The A allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 8, band 8q11.23 — between genes, 5.9 kb from RN7SL250P.

What each result means

A/A Two copies of the version the research linked to Intracranial aneurysm. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Intracranial aneurysm. That is a smaller link than two copies.
G/G No copy of the version the research linked to Intracranial aneurysm. This is the starting point the study compared everyone against.
Source

Questions about rs10958409

What is rs10958409?

rs10958409 is a single position in the genome, in or near the SOX17 gene. Published research associates it with intracranial aneurysm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10958409 linked to?

On MyGeneLog this position is linked to Intracranial Aneurysm. The research behind each link, and its sources, are set out on that condition page.

Does having rs10958409 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10958409 come from?

GWAS Catalog, Nat Genet 2008, PMID:18997786. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Intracranial aneurysm (rs10958409). MyGeneLog™. https://www.mygenelog.com/variants/rs10958409

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