DNAH11 · rs10950865
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
Its strongest genetic-study result is p = 10−12, with 3 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 341,875 European ancestry individuals, 6,003 African ancestry individuals, 7,319 South Asian ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.0187 lower (95% confidence interval 0.014-0.024); p = 6 × 10−13.
Where it sits Chromosome 7, band 7p15.3 — in an intron of DNAH11.
rs10950865 is a single position in the genome, in or near the DNAH11 gene. Published research associates it with low density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Low density lipoprotein cholesterol levels (rs10950865). MyGeneLog™. https://www.mygenelog.com/variants/rs10950865