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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 34,461 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 1.08 lower (95% confidence interval 0.95-1.22); p = 4 × 10−54.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 6, band 6p22.3 — in the 3′ untranslated region of NHLRC1.
What ClinVar records
ClassificationBenign for Lafora disease; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-01-13.
ClinVar record 356063NM_198586.3(NHLRC1):c.*621T>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Intrinsic epigenetic age acceleration. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Intrinsic epigenetic age acceleration. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Intrinsic epigenetic age acceleration. That is the strongest link of the three results. A link in a study is not a diagnosis.
Genome biology · 2021 · PMID 34187551 · open access
Questions about rs10949481
What is rs10949481?
rs10949481 is a single position in the genome, in or near the NHLRC1 gene. Published research associates it with intrinsic epigenetic age acceleration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10949481 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10949481 come from?
GWAS Catalog, Genome biology 2021, PMID:34187551. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Intrinsic epigenetic age acceleration (rs10949481). MyGeneLog™. https://www.mygenelog.com/variants/rs10949481