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Phospholipids to Total Lipids in Medium HDL percentage

KCNK5 · rs10947786

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs10947786 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs10947786 rs10947786 KCNK5

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.02 % lower (95% confidence interval 0.02-0.02); p = 8 × 10−14.

Where it sits Chromosome 6, band 6p21.2 — in the 3′ untranslated region of KCNK5.

What each result means

A/A Two copies of the version the research linked to Phospholipids to Total Lipids in Medium HDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Phospholipids to Total Lipids in Medium HDL percentage. That is a smaller link than two copies.
G/G No copy of the version the research linked to Phospholipids to Total Lipids in Medium HDL percentage. This is the starting point the study compared everyone against.
Source

Questions about rs10947786

What is rs10947786?

rs10947786 is a single position in the genome, in or near the KCNK5 gene. Published research associates it with phospholipids to total lipids in medium hdl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10947786 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs10947786 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10947786 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Phospholipids to Total Lipids in Medium HDL percentage (rs10947786). MyGeneLog™. https://www.mygenelog.com/variants/rs10947786

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