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Thyroid peroxidase antibody positivity

BACH2 · rs10944479

Where this position leads

Condition: Thyroid Autoimmunity (TPO Antibodies)

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thyroid peroxidase antibody positivity compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thyroid peroxidase antibody positivity.

G/G Published research associates this genotype with typical/baseline likelihood of Thyroid peroxidase antibody positivity — no copies of the reported risk allele.

Source

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

Medici M, Porcu E, Pistis G, Teumer A, Brown SJ, Jensen RA, Rawal R, Roef GL, Plantinga TS, Vermeulen SH, Lahti J, Simmonds MJ

and 106 more — show all

Husemoen LL, Freathy RM, Shields BM, Pietzner D, Nagy R, Broer L, Chaker L, Korevaar TI, Plia MG, Sala C, Völker U, Richards JB, Sweep FC, Gieger C, Corre T, Kajantie E, Thuesen B, Taes YE, Visser WE, Hattersley AT, Kratzsch J, Hamilton A, Li W, Homuth G, Lobina M, Mariotti S, Soranzo N, Cocca M, Nauck M, Spielhagen C, Ross A, Arnold A, van de Bunt M, Liyanarachchi S, Heier M, Grabe HJ, Masciullo C, Galesloot TE, Lim EM, Reischl E, Leedman PJ, Lai S, Delitala A, Bremner AP, Philips DI, Beilby JP, Mulas A, Vocale M, Abecasis G, Forsen T, James A, Widen E, Hui J, Prokisch H, Rietzschel EE, Palotie A, Feddema P, Fletcher SJ, Schramm K, Rotter JI, Kluttig A, Radke D, Traglia M, Surdulescu GL, He H, Franklyn JA, Tiller D, Vaidya B, de Meyer T, Jørgensen T, Eriksson JG, O'Leary PC, Wichmann E, Hermus AR, Psaty BM, Ittermann T, Hofman A, Bosi E, Schlessinger D, Wallaschofski H, Pirastu N, Aulchenko YS, de la Chapelle A, Netea-Maier RT, Gough SC, Meyer Zu Schwabedissen H, Frayling TM, Kaufman JM, Linneberg A, Räikkönen K, Smit JW, Kiemeney LA, Rivadeneira F, Uitterlinden AG, Walsh JP, Meisinger C, den Heijer M, Visser TJ, Spector TD, Wilson SG, Völzke H, Cappola A, Toniolo D, Sanna S, Naitza S, Peeters RP

PLoS genetics · 2014 · PMID 24586183 · open access

Questions about rs10944479

What is rs10944479?

rs10944479 is a single position in the genome, in or near the BACH2 gene. Published research associates it with thyroid peroxidase antibody positivity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10944479 linked to?

On MyGeneLog this position is linked to Thyroid Autoimmunity (TPO Antibodies). The research behind each link, and its sources, are set out on that condition page.

Does having rs10944479 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10944479 come from?

GWAS Catalog, PLoS Genet 2014, PMID:24586183. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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