Standard

Body mass index

MIR4280HG · rs10942491

Where this position leads

Condition: Childhood Body Mass Index

rs10942491 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition rs10942491 rs10942491 MIR4280HG

What the study found

Who was studied 359,983 European ancestry individuals, 163,835 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0118 lower (95% confidence interval 0.0079-0.0157); p = 2 × 10−9.

Where it sits Chromosome 5, band 5q14.3 — in an intron of MIR4280HG.

What each result means

C/C Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
G/G No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
Source

Questions about rs10942491

What is rs10942491?

rs10942491 is a single position in the genome, in or near the MIR4280HG gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10942491 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs10942491 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10942491 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index (rs10942491). MyGeneLog™. https://www.mygenelog.com/variants/rs10942491

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