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Female infertility (all causes)

GREB1 · rs10929759

What the study found

Who was studied 42,629 European, South Asian, African American or Afro-Caribbean and other admixed ancestry female cases, 740,619 European, South Asian, African American or Afro-Caribbean and other admixed ancestry female cases female controls.

The effect Each copy of the G allele carried 0.95 times the odds of Female infertility (all causes) (95% confidence interval 0.938-0.966); p = 1 × 10−10.

How common The G allele had a frequency of about 46% in the people studied.

Where it sits Chromosome 2, band 2p25.1 — in an intron of GREB1.

What each result means

C/C No copy of the version the research linked to Female infertility (all causes). This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Female infertility (all causes). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Female infertility (all causes). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10929759

What is rs10929759?

rs10929759 is a single position in the genome, in or near the GREB1 gene. Published research associates it with female infertility (all causes). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10929759 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10929759 come from?

GWAS Catalog, Nature genetics 2025, PMID:40229599. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Female infertility (all causes) (rs10929759). MyGeneLog™. https://www.mygenelog.com/variants/rs10929759

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