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Diverticulitis

ARHGAP15 · rs10928187

What the study found

Who was studied 1,265 European ancestry, African ancestry, NR cases, 9,200 European ancestry, African ancestry, NR controls.

The effect Each copy of the G allele carried 1.42 times the odds of Diverticulitis (95% confidence interval 1.32-1.52); p = 7 × 10−12.

How common The G allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 2, band 2q22.3 — in an intron of ARHGAP15.

What each result means

A/A No copy of the version the research linked to Diverticulitis. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Diverticulitis. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Diverticulitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10928187

What is rs10928187?

rs10928187 is a single position in the genome, in or near the ARHGAP15 gene. Published research associates it with diverticulitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10928187 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10928187 come from?

GWAS Catalog, PloS one 2023, PMID:37196047. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Diverticulitis (rs10928187). MyGeneLog™. https://www.mygenelog.com/variants/rs10928187

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