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monocyte (fraction, minimum, inv-norm transformed)

NOS1AP · rs10918705

Where this position leads

Drug: QT-prolonging medicines

rs10918705 Drug: QT-prolonging medicines QT-prolonging medicines Drug rs10918705 rs10918705 NOS1AP

What the study found

Who was studied 82,924 African American or Afro-Caribbean individuals, 45,327 Hispanic or Latin American individuals, 4,359 East Asian ancestry individuals, 296,975 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0347 lower (95% confidence interval 0.026-0.043); p = 1 × 10−16.

How common The C allele had a frequency of about 81% in the people studied.

Where it sits Chromosome 1, band 1q23.3 — in an intron of NOS1AP.

What each result means

C/C Two copies of the version the research linked to monocyte (fraction, minimum, inv-norm transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to monocyte (fraction, minimum, inv-norm transformed). That is a smaller link than two copies.
T/T No copy of the version the research linked to monocyte (fraction, minimum, inv-norm transformed). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs10918705

What is rs10918705?

rs10918705 is a single position in the genome, in or near the NOS1AP gene. Published research associates it with monocyte (fraction, minimum, inv-norm transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs10918705 affect how medicines work?

NOS1AP carries pharmacogenomic findings for QT-prolonging medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs10918705 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10918705 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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monocyte (fraction, minimum, inv-norm transformed) (rs10918705). MyGeneLog™. https://www.mygenelog.com/variants/rs10918705

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