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Who was studied 228,926 European ancestry cases, 1,611,415 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0273 lower (95% confidence interval 0.02-0.035); p = 1 × 10−12.
How common The A allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 1, band 1p36.13 — in an intron of CAPZB.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40645996 · open access
Questions about rs10917449
What is rs10917449?
rs10917449 is a single position in the genome, in or near the CAPZB gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10917449 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs10917449 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10917449 come from?
GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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