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Who was studied 2,071 Dutch ancestry individuals; replicated in 1,203 individuals.
The effect
Each copy of the A allele shifted the measure 0.31 lower (95% confidence interval 0.23-0.39); p = 2 × 10−13.
How common The A allele had a frequency of about 81% in the people studied.
Where it sits Chromosome 1, band 1q42.13 — between genes, 8.1 kb from ZNF847P.
What each result means
A/ATwo copies of the version the research linked to Thumb osteoarthritis severity (hand Klsum). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Thumb osteoarthritis severity (hand Klsum). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Thumb osteoarthritis severity (hand Klsum). This is the starting point the study compared everyone against.
Annals of the rheumatic diseases · 2021 · PMID 33055079 · open access
Questions about rs10916199
What is rs10916199?
rs10916199 is a single position in the genome, in or near the ZNF678 gene. Published research associates it with thumb osteoarthritis severity (hand klsum). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10916199 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs10916199 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10916199 come from?
GWAS Catalog, Annals of the rheumatic diseases 2021, PMID:33055079. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thumb osteoarthritis severity (hand Klsum) (rs10916199). MyGeneLog™. https://www.mygenelog.com/variants/rs10916199