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Sensitive

Systemic sclerosis

TNFSF4 · rs10912594

Where this position leads

Condition: Systemic Sclerosis

rs10912594 Condition: Systemic Sclerosis Systemic Sclerosis Condition rs10912594 rs10912594 TNFSF4

What the study found

Who was studied 9,095 European ancestry cases, 17,584 European ancestry controls, 1,428 Japanese ancestry cases, 112,599 Japanese ancestry controls.

The effect Each copy of the C allele shifted the measure 0.062 lower (95% confidence interval 0.021-0.103); p = 6 × 10−12.

Where it sits Chromosome 1, band 1q25.1 — in an intron of TNFSF4.

What each result means

C/C Two copies of the version the research linked to Systemic sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Systemic sclerosis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Systemic sclerosis. This is the starting point the study compared everyone against.
Source
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
Ishikawa Y, Tanaka N, Asano Y, Kodera M, Shirai Y, Akahoshi M, Hasegawa M, Matsushita T, Saito K, Motegi SI, Yoshifuji H, Yoshizaki A
and 60 more — show all
Kohmoto T, Takagi K, Oka A, Kanda M, Tanaka Y, Ito Y, Nakano K, Kasamatsu H, Utsunomiya A, Sekiguchi A, Niiro H, Jinnin M, Makino K, Makino T, Ihn H, Yamamoto M, Suzuki C, Takahashi H, Nishida E, Morita A, Yamamoto T, Fujimoto M, Kondo Y, Goto D, Sumida T, Ayuzawa N, Yanagida H, Horita T, Atsumi T, Endo H, Shima Y, Kumanogoh A, Hirata J, Otomo N, Suetsugu H, Koike Y, Tomizuka K, Yoshino S, Liu X, Ito S, Hikino K, Suzuki A, Momozawa Y, Ikegawa S, Tanaka Y, Ishikawa O, Takehara K, Torii T, Sato S, Okada Y, Mimori T, Matsuda F, Matsuda K, Amariuta T, Imoto I, Matsuo K, Kuwana M, Kawaguchi Y, Ohmura K, Terao C
Nature communications · 2024 · PMID 38296975 · open access

Questions about rs10912594

What is rs10912594?

rs10912594 is a single position in the genome, in or near the TNFSF4 gene. Published research associates it with systemic sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10912594 linked to?

On MyGeneLog this position is linked to Systemic Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs10912594 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10912594 come from?

GWAS Catalog, Nature communications 2024, PMID:38296975. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Systemic sclerosis (rs10912594). MyGeneLog™. https://www.mygenelog.com/variants/rs10912594

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