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Asthma

TNFSF4 · rs10912564

Where this position leads

Condition: Asthma

What the study found

Who was studied 64,538 European ancestry cases, 239,321 European ancestry controls.

The effect Each copy of the T allele carried 1.05 times the odds of Asthma (95% confidence interval 1.03803296327663-1.06490626907847); p = 2 × 10⁻¹⁴.

How common The T allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 1, band 1q25.1 — in an intron of TNFSF4.

What each result means

C/C No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Asthma. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

Han Y, Jia Q, Jahani PS, Hurrell BP, Pan C, Huang P, Gukasyan J, Woodward NC, Eskin E, Gilliland FD, Akbari O, Hartiala JA

and 1 more — show all

Allayee H

Nature communications · 2020 · PMID 32296059 · open access

Questions about rs10912564

What is rs10912564?

rs10912564 is a single position in the genome, in or near the TNFSF4 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10912564 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs10912564 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10912564 come from?

GWAS Catalog, Nature communications 2020, PMID:32296059. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs10912564). MyGeneLog™. https://www.mygenelog.com/variants/rs10912564

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