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Who was studied 4,910 Chinese ancestry cases, 68,140 Chinese ancestry controls.
The effect
Each copy of the C allele carried 1.26 times the odds of Subclinical hypothyroidism in pregnancy (95% confidence interval 1.19-1.33); p = 7 × 10−15.
How common The C allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 9, band 9q34.2 — in the 3′ untranslated region of ABO.
What each result means
A/ANo copy of the version the research linked to Subclinical hypothyroidism in pregnancy. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Subclinical hypothyroidism in pregnancy. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Subclinical hypothyroidism in pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39266554 · open access
Questions about rs10901251
What is rs10901251?
rs10901251 is a single position in the genome, in or near the ABO gene. Published research associates it with subclinical hypothyroidism in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10901251 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs10901251 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10901251 come from?
GWAS Catalog, Nature communications 2024, PMID:39266554. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Subclinical hypothyroidism in pregnancy (rs10901251). MyGeneLog™. https://www.mygenelog.com/variants/rs10901251