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Coronary artery calcification

near LINC00841 · rs10899970

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 28,655 European ancestry individuals, 8,065 African American individuals.

The effect Each copy of the A allele shifted the measure 0.095 higher (95% confidence interval 0.062-0.128); p = 3 × 10⁻⁸.

How common The A allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 10, band 10q11.21 — between genes, 35.8 kb from LINC00841.

What each result means

A/A Two copies of the version the research linked to Coronary artery calcification. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Coronary artery calcification. That is a smaller link than two copies.

G/G No copy of the version the research linked to Coronary artery calcification. This is the starting point the study compared everyone against.

Source

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Kavousi M, Bos MM, Barnes HJ, Lino Cardenas CL, Wong D, Lu H, Hodonsky CJ, Landsmeer LPL, Turner AW, Kho M, Hasbani NR, de Vries PS

and 77 more — show all

Bowden DW, Chopade S, Deelen J, Benavente ED, Guo X, Hofer E, Hwang SJ, Lutz SM, Lyytikäinen LP, Slenders L, Smith AV, Stanislawski MA, van Setten J, Wong Q, Yanek LR, Becker DM, Beekman M, Budoff MJ, Feitosa MF, Finan C, Hilliard AT, Kardia SLR, Kovacic JC, Kral BG, Langefeld CD, Launer LJ, Malik S, Hoesein FAAM, Mokry M, Schmidt R, Smith JA, Taylor KD, Terry JG, van der Grond J, van Meurs J, Vliegenthart R, Xu J, Young KA, Zilhão NR, Zweiker R, Assimes TL, Becker LC, Bos D, Carr JJ, Cupples LA, de Kleijn DPV, de Winther M, den Ruijter HM, Fornage M, Freedman BI, Gudnason V, Hingorani AD, Hokanson JE, Ikram MA, Išgum I, Jacobs DR Jr, Kähönen M, Lange LA, Lehtimäki T, Pasterkamp G, Raitakari OT, Schmidt H, Slagboom PE, Uitterlinden AG, Vernooij MW, Bis JC, Franceschini N, Psaty BM, Post WS, Rotter JI, Björkegren JLM, O'Donnell CJ, Bielak LF, Peyser PA, Malhotra R, van der Laan SW, Miller CL

Nature genetics · 2023 · PMID 37770635

Questions about rs10899970

What is rs10899970?

rs10899970 is a single position in the genome, in or near the near LINC00841 gene. Published research associates it with coronary artery calcification. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10899970 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10899970 come from?

GWAS Catalog, GWAS Catalog n.d., PMID:37770635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Coronary artery calcification (rs10899970). MyGeneLog™. https://www.mygenelog.com/variants/rs10899970

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