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Neuroblastoma (11q deletion)

MMP20 · rs10895322

Where this position leads

What the study found

Who was studied 113 European ancestry cases, 5,109 European ancestry controls; replicated in 44 European ancestry cases, 1,902 European ancestry controls.

The effect Each copy of the G allele carried 2.76 times the odds of Neuroblastoma (11q deletion) (95% confidence interval 2.015-3.789); p = 3 × 10⁻¹⁰.

How common The G allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 11, band 11q22.2 — in an intron of MMP20.

What ClinVar records

Classification not provided; no classification provided (0 of 4 stars, 1 submitter). ClinVar record 162146 NM_004771.4(MMP20):c.954-4768T>C

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Neuroblastoma (11q deletion) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neuroblastoma (11q deletion).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neuroblastoma (11q deletion) compared to the general population.

Source

Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk

Chang X, Zhao Y, Hou C, Glessner J, McDaniel L, Diamond MA, Thomas K, Li J, Wei Z, Liu Y, Guo Y, Mentch FD

and 9 more — show all

Qiu H, Kim C, Evans P, Vaksman Z, Diskin SJ, Attiyeh EF, Sleiman P, Maris JM, Hakonarson H

Nature communications · 2017 · PMID 28924153 · open access

Questions about rs10895322

What is rs10895322?

rs10895322 is a single position in the genome, in or near the MMP20 gene. Published research associates it with neuroblastoma (11q deletion). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10895322 linked to?

On MyGeneLog this position is linked to Neuroblastoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs10895322 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10895322 come from?

GWAS Catalog, Nat Commun 2017, PMID:28924153. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroblastoma (11q deletion) (rs10895322). MyGeneLog™. https://www.mygenelog.com/variants/rs10895322

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