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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 410,603 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.00832 lower (95% confidence interval 0.006-0.0106); p = 2 × 10−12.
How common The C allele had a frequency of about 55% in the people studied.
Where it sits Chromosome 11, band 11q23.2 — between genes, 1.9 kb from DRD2.
What each result means
C/CTwo copies of the version the research linked to Positive affect. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Positive affect. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Positive affect. This is the starting point the study compared everyone against.
rs10891549 is a single position in the genome, in or near the near DRD2 gene. Published research associates it with positive affect. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10891549 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10891549 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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