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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 390,964 European ancestry individuals; replicated in 105,030 East Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 6.54 z-score higher; p = 6 × 10−11.
How common The A allele had a frequency of about 49% in the people studied.
Where it sits Chromosome 10, band 10q23.32 — between genes, 18.7 kb from TNKS2.
What each result means
A/ATwo copies of the version the research linked to Serum alkaline phosphatase levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Serum alkaline phosphatase levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Serum alkaline phosphatase levels. This is the starting point the study compared everyone against.
Nature communications · 2021 · PMID 33547301 · open access
Questions about rs10881988
What is rs10881988?
rs10881988 is a single position in the genome, in or near the TNKS2 gene. Published research associates it with serum alkaline phosphatase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10881988 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10881988 come from?
GWAS Catalog, Nature communications 2021, PMID:33547301. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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