Standard

Height

YAF2 · rs10880274

Where this position leads

Condition: Height

rs10880274 Condition: Height Height Condition rs10880274 rs10880274 YAF2

What the study found

Who was studied 5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0099 higher (95% confidence interval 0.0083-0.0115); p = 4 × 10−38.

How common The C allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 12, band 12q12 — in an intron of YAF2.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Height compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Height.
T/T Published research associates this genotype with typical/baseline likelihood of Height — no copies of the reported risk allele.
Source

Questions about rs10880274

What is rs10880274?

rs10880274 is a single position in the genome, in or near the YAF2 gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10880274 linked to?

On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.

Does having rs10880274 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10880274 come from?

GWAS Catalog, Nature 2022, PMID:36224396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Height (rs10880274). MyGeneLog™. https://www.mygenelog.com/variants/rs10880274

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