Sensitive

Schizophrenia

PPP1R13B · rs10873538

Where this position leads

Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk)

rs10873538 Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk) Autism Spectrum Disorder and Schizo… Condition rs10873538 rs10873538 PPP1R13B

What the study found

Who was studied 53,386 European ancestry cases, 77,258 European ancestry controls, 14,004 East Asian ancestry cases, 16,757 East Asian ancestry controls, 6,152 African American cases, 3,918 African American controls, 1,234 Latino cases, 3,090 Latino controls; replicated in 1,979 European ancestry cases, 142,626 European ancestry controls.

The effect Each copy of the T allele carried 0.94 times the odds of Schizophrenia (95% confidence interval 0.93-0.96); p = 5 × 10−15.

How common The T allele had a frequency of about 68% in the people studied.

Where it sits Chromosome 14, band 14q32.33 — in an intron of PPP1R13B.

What each result means

G/G No copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10873538

What is rs10873538?

rs10873538 is a single position in the genome, in or near the PPP1R13B gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10873538 linked to?

On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.

Does having rs10873538 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10873538 come from?

GWAS Catalog, Nature 2022, PMID:35396580. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Schizophrenia (rs10873538). MyGeneLog™. https://www.mygenelog.com/variants/rs10873538

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