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Who was studied 15,009 European ancestry cases, 41,628 European ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 3 × 10−8.
How common The T allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 1, band 1p13.2 — in an intron of DCLRE1B.
What each result means
C/CNo copy of the version the research linked to Cardiovascular disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Cardiovascular disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Cardiovascular disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33893285 · open access
Questions about rs10858023
What is rs10858023?
rs10858023 is a single position in the genome, in or near the DCLRE1B gene. Published research associates it with cardiovascular disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10858023 linked to?
On MyGeneLog this position is linked to Cardiovascular Disease Risk Factors. The research behind each link, and its sources, are set out on that condition page.
Does having rs10858023 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10858023 come from?
GWAS Catalog, Nature communications 2021, PMID:33893285. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 13211Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others11Total13Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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