Who was studied 169,545 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0464 higher (95% confidence interval 0.038-0.055); p = 7 × 10−27.
How common The G allele had a frequency of about 76% in the people studied.
Where it sits Chromosome 12, band 12p13.31 — in the 5′ untranslated region of LTBR.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Granulocyte percentage of myeloid white cells — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Granulocyte percentage of myeloid white cells.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Granulocyte percentage of myeloid white cells compared to the general population.
rs10849448 is a single position in the genome, in or near the LTBR gene. Published research associates it with granulocyte percentage of myeloid white cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10849448 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs10849448 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10849448 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.