Body mass index or spine osteoarthritis (pleiotropy)
near ZCCHC8 · rs10846921
0 2219228Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot9Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others8Total22Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 806,834 European ancestry BMI individuals, 28,372 European ancestry spine osteoarthritis cases, 305,578 European ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 2 × 10−28.
Where it sits Chromosome 12, band 12q24.31 — between genes, 12.8 kb from ZCCHC8.
What each result means
A/ATwo copies of the version the research linked to Body mass index or spine osteoarthritis (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Body mass index or spine osteoarthritis (pleiotropy). That is a smaller link than two copies.
C/CNo copy of the version the research linked to Body mass index or spine osteoarthritis (pleiotropy). This is the starting point the study compared everyone against.
Osteoarthritis and cartilage · 2023 · PMID 36889626
Questions about rs10846921
What is rs10846921?
rs10846921 is a single position in the genome, in or near the near ZCCHC8 gene. Published research associates it with body mass index or spine osteoarthritis (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10846921 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs10846921 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10846921 come from?
GWAS Catalog, Osteoarthritis and cartilage 2023, PMID:36889626. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2219228Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot9Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others8Total22Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Body mass index or spine osteoarthritis (pleiotropy) (rs10846921). MyGeneLog™. https://www.mygenelog.com/variants/rs10846921