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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 25,890 European ancestry cases, 743,585 European ancestry controls, 897 African American or Afro-Caribbean cases, 3,109 African American or Afro-Caribbean controls, 1,612 Hispanic or Latin American cases, 2,180 Hispanic or Latin American controls, 621 East Asian ancestry cases, 86,796 East Asian ancestry controls.
The effect
Each copy of the C allele carried 1.09 times the odds of Kidney cancer (95% confidence interval 1.06-1.12); p = 2 × 10−8.
How common The C allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 12, band 12q24.31 — in an intron of SCARB1.
What each result means
C/CTwo copies of the version the research linked to Kidney cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Kidney cancer. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Kidney cancer. This is the starting point the study compared everyone against.
rs10846758 is a single position in the genome, in or near the SCARB1 gene. Published research associates it with kidney cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10846758 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10846758 come from?
GWAS Catalog, Nature genetics 2024, PMID:38671320. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Kidney cancer (rs10846758). MyGeneLog™. https://www.mygenelog.com/variants/rs10846758