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Insomnia

DNAH10 · rs10846577

Where this position leads

Condition: Insomnia

rs10846577 Condition: Insomnia Insomnia Condition rs10846577 rs10846577 DNAH10

What the study found

Who was studied 593,724 European ancestry cases, 1,771,286 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.006 lower (95% confidence interval 0.004-0.008); p = 1 × 10−11.

Where it sits Chromosome 12, band 12q24.31 — in an intron of DNAH10.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Insomnia — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Insomnia.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Insomnia compared to the general population.
Source

Questions about rs10846577

What is rs10846577?

rs10846577 is a single position in the genome, in or near the DNAH10 gene. Published research associates it with insomnia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10846577 linked to?

On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.

Does having rs10846577 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10846577 come from?

GWAS Catalog, Nature genetics 2022, PMID:35835914. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Insomnia (rs10846577). MyGeneLog™. https://www.mygenelog.com/variants/rs10846577

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