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Neutrophil count

FOXJ2 · rs10846411

Where this position leads

Condition: Blood Cell Counts

rs10846411 Condition: Blood Cell Counts Blood Cell Counts Condition rs10846411 rs10846411 FOXJ2

What the study found

Who was studied 519,288 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0167 SD unit higher (95% confidence interval 0.013-0.021); p = 1 × 10−15.

How common The G allele had a frequency of about 69% in the people studied.

Where it sits Chromosome 12, band 12p13.31 — in the 3′ untranslated region of FOXJ2.

What each result means

A/A No copy of the version the research linked to Neutrophil count. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Neutrophil count. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Neutrophil count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10846411

What is rs10846411?

rs10846411 is a single position in the genome, in or near the FOXJ2 gene. Published research associates it with neutrophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10846411 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs10846411 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10846411 come from?

GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Neutrophil count (rs10846411). MyGeneLog™. https://www.mygenelog.com/variants/rs10846411

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