Standard

Cigarettes smoked per day (MTAG)

LMO3 · rs10846380

Where this position leads

Condition: Smoking Behaviour and Nicotine Dependence

What the study found

Who was studied up to 403,928 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0143 lower (95% confidence interval 0.0099-0.0187); p = 1 × 10⁻¹⁰.

How common The T allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 12, band 12p12.3 — in an intron of LMO3.

What each result means

C/C No copy of the version the research linked to Cigarettes smoked per day (MTAG). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Cigarettes smoked per day (MTAG). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Cigarettes smoked per day (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain J, McGuire D, Tian C, Zhan X, Choquet H

and 111 more — show all

Docherty AR, Faul JD, Foerster JR, Fritsche LG, Gabrielsen ME, Gordon SD, Haessler J, Hottenga JJ, Huang H, Jang SK, Jansen PR, Ling Y, Mägi R, Matoba N, McMahon G, Mulas A, Orrù V, Palviainen T, Pandit A, Reginsson GW, Skogholt AH, Smith JA, Taylor AE, Turman C, Willemsen G, Young H, Young KA, Zajac GJM, Zhao W, Zhou W, Bjornsdottir G, Boardman JD, Boehnke M, Boomsma DI, Chen C, Cucca F, Davies GE, Eaton CB, Ehringer MA, Esko T, Fiorillo E, Gillespie NA, Gudbjartsson DF, Haller T, Harris KM, Heath AC, Hewitt JK, Hickie IB, Hokanson JE, Hopfer CJ, Hunter DJ, Iacono WG, Johnson EO, Kamatani Y, Kardia SLR, Keller MC, Kellis M, Kooperberg C, Kraft P, Krauter KS, Laakso M, Lind PA, Loukola A, Lutz SM, Madden PAF, Martin NG, McGue M, McQueen MB, Medland SE, Metspalu A, Mohlke KL, Nielsen JB, Okada Y, Peters U, Polderman TJC, Posthuma D, Reiner AP, Rice JP, Rimm E, Rose RJ, Runarsdottir V, Stallings MC, Stančáková A, Stefansson H, Thai KK, Tindle HA, Tyrfingsson T, Wall TL, Weir DR, Weisner C, Whitfield JB, Winsvold BS, Yin J, Zuccolo L, Bierut LJ, Hveem K, Lee JJ, Munafò MR, Saccone NL, Willer CJ, Cornelis MC, David SP, Hinds DA, Jorgenson E, Kaprio J, Stitzel JA, Stefansson K, Thorgeirsson TE, Abecasis G, Liu DJ, Vrieze S

23andMe Research Team · HUNT All-In Psychiatry

Nature genetics · 2019 · PMID 30643251 · open access

Questions about rs10846380

What is rs10846380?

rs10846380 is a single position in the genome, in or near the LMO3 gene. Published research associates it with cigarettes smoked per day (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10846380 linked to?

On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.

Does having rs10846380 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10846380 come from?

GWAS Catalog, Nature genetics 2019, PMID:30643251. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cigarettes smoked per day (MTAG) (rs10846380). MyGeneLog™. https://www.mygenelog.com/variants/rs10846380

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