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Medication use (antidepressants)

SLC15A5 · rs10846305

Where this position leads

Condition: Medication Use as a Genetic Trait

What the study found

Who was studied 33,757 European ancestry cases, 270,405 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0486 higher (95% confidence interval 0.032-0.065); p = 5 × 10⁻⁹.

How common The G allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 12, band 12p12.3 — between genes, 30.6 kb from SLC15A5.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Medication use (antidepressants) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Medication use (antidepressants).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Medication use (antidepressants) compared to the general population.

Source

Genome-wide association study of medication-use and associated disease in the UK Biobank

Wu Y, Byrne EM, Zheng Z, Kemper KE, Yengo L, Mallett AJ, Yang J, Visscher PM, Wray NR

Nature communications · 2019 · PMID 31015401 · open access

Questions about rs10846305

What is rs10846305?

rs10846305 is a single position in the genome, in or near the SLC15A5 gene. Published research associates it with medication use (antidepressants). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10846305 linked to?

On MyGeneLog this position is linked to Medication Use as a Genetic Trait. The research behind each link, and its sources, are set out on that condition page.

Does having rs10846305 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10846305 come from?

GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Medication use (antidepressants) (rs10846305). MyGeneLog™. https://www.mygenelog.com/variants/rs10846305

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