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Weight

GUCY2C-AS1 · rs10846059

Where this position leads

Condition: Obesity and Body Weight

rs10846059 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs10846059 rs10846059 GUCY2C-AS1

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0144 higher (95% confidence interval 0.0099-0.0189); p = 4 × 10−10.

Where it sits Chromosome 12, band 12p12.3 — in a non-coding transcript of GUCY2C-AS1.

What each result means

C/C No copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Weight. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10846059

What is rs10846059?

rs10846059 is a single position in the genome, in or near the GUCY2C-AS1 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10846059 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs10846059 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10846059 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs10846059). MyGeneLog™. https://www.mygenelog.com/variants/rs10846059

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