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Who was studied 88,842 European ancestry cases, 397,208 European ancestry controls, 899 Japanese ancestry cases, 3,396 Japanese ancestry controls.
The effect
Each copy of the A allele carried 1.04 times the odds of Osteoarthritis of the hip or knee (95% confidence interval 1.028877334-1.056257245); p = 5 × 10−10.
How common The A allele had a frequency of about 42% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SOX5.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis of the hip or knee. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Osteoarthritis of the hip or knee. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Osteoarthritis of the hip or knee. This is the starting point the study compared everyone against.
rs10842226 is a single position in the genome, in or near the SOX5 gene. Published research associates it with osteoarthritis of the hip or knee. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10842226 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs10842226 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10842226 come from?
GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Osteoarthritis of the hip or knee (rs10842226). MyGeneLog™. https://www.mygenelog.com/variants/rs10842226