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Weight

KIAA1217 · rs10828538

Where this position leads

Condition: Obesity and Body Weight

rs10828538 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs10828538 rs10828538 KIAA1217

What the study found

Who was studied 360,116 European ancestry individuals, 165,419 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0199 lower (95% confidence interval 0.014-0.026); p = 4 × 10−10.

Where it sits Chromosome 10, band 10p12.2 — inside KIAA1217.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Weight — no copies of the reported risk allele.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Weight.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Weight compared to the general population.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs10828538

What is rs10828538?

rs10828538 is a single position in the genome, in or near the KIAA1217 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10828538 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs10828538 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10828538 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs10828538). MyGeneLog™. https://www.mygenelog.com/variants/rs10828538

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