Sensitive

Rheumatoid arthritis

ARID5B · rs10821944

Where this position leads

Condition: Rheumatoid Arthritis

rs10821944 Condition: Rheumatoid Arthritis Rheumatoid Arthritis Condition rs10821944 rs10821944 ARID5B

What the study found

Who was studied 4,074 Japanese ancestry cases, 16,891 Japanese ancestry controls; replicated in 5,277 Japanese ancestry cases, 21,684 Japanese ancestry controls.

The effect Each copy of the G allele carried 1.16 times the odds of Rheumatoid arthritis (95% confidence interval 1.12-1.20); p = 6 × 10−18.

How common The G allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 10, band 10q21.2 — in an intron of ARID5B.

What each result means

G/G Two copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.
T/T No copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.
Source

Questions about rs10821944

What is rs10821944?

rs10821944 is a single position in the genome, in or near the ARID5B gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10821944 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs10821944 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10821944 come from?

GWAS Catalog, Nat Genet 2012, PMID:22446963. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Rheumatoid arthritis (rs10821944). MyGeneLog™. https://www.mygenelog.com/variants/rs10821944

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