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Who was studied 744 Han Chinese ancestry cases, 895 Han Chinese ancestry controls; replicated in 3,338 Han Chinese ancestry cases, 5,792 Han Chinese ancestry controls.
The effect
Each copy of the A allele carried 1.51 times the odds of Polycystic ovary syndrome (95% confidence interval 1.37-1.65); p = 9 × 10−18.
How common The A allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 9, band 9q33.3 — in an intron of DENND1A.
What each result means
A/ATwo copies of the version the research linked to Polycystic ovary syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Polycystic ovary syndrome. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Polycystic ovary syndrome. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10818854
What is rs10818854?
rs10818854 is a single position in the genome, in or near the DENND1A gene. Published research associates it with polycystic ovary syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10818854 linked to?
On MyGeneLog this position is linked to Polycystic Ovary Syndrome. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs10818854?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers), fertility (1 papers), longevity and ageing (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10818854 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10818854 come from?
GWAS Catalog, Nat Genet 2010, PMID:21151128. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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