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Who was studied 37,850 European, East Asian, African, South Asian, Middle Eastern, Admixed or unknown ancestry cases, 556,334 European, East Asian, African, South Asian, Middle Eastern, Admixed or unknown ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0559 log odds ratio lower (95% confidence interval 0.037-0.074); p = 2 × 10−9.
Where it sits Chromosome 9, band 9p24.1 — in an intron of PLGRKT.
What each result means
A/ATwo copies of the version the research linked to Hashimoto thyroiditis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Hashimoto thyroiditis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hashimoto thyroiditis. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42527560 · open access
Questions about rs10815220
What is rs10815220?
rs10815220 is a single position in the genome, in or near the PLGRKT gene. Published research associates it with hashimoto thyroiditis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10815220 linked to?
On MyGeneLog this position is linked to Lymphocytic Thyroiditis (Hashimoto's). The research behind each link, and its sources, are set out on that condition page.
Does having rs10815220 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10815220 come from?
GWAS Catalog, Nature genetics 2026, PMID:42527560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1214124Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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