Sensitive

Type 2 diabetes

GLIS3 · rs10814916

Where this position leads

Condition: Type 2 Diabetes

rs10814916 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs10814916 rs10814916 GLIS3

What the study found

Who was studied 1,839 Han Chinese ancestry cases, 1,873 Han Chinese ancestry controls; replicated in 15,979 East Asian ancestry cases, 19,360 East Asian ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 159 Filipino ancestry cases, 1,624 Filipino ancestry controls.

The effect Each copy of the C allele carried 1.11 times the odds of Type 2 diabetes (95% confidence interval 1.08-1.15); p = 6 × 10−12.

How common The C allele had a frequency of about 44% in the people studied.

Where it sits Chromosome 9, band 9p24.2 — in an intron of GLIS3.

What each result means

A/A No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10814916

What is rs10814916?

rs10814916 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10814916 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10814916?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10814916 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10814916 come from?

GWAS Catalog, Diabetes 2012, PMID:22961080. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs10814916). MyGeneLog™. https://www.mygenelog.com/variants/rs10814916

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