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Thyroid stimulating hormone levels

GLIS3 · rs10814915

Where this position leads

Condition: Thyroid Stimulating Hormone (TSH) Levels

rs10814915 Condition: Thyroid Stimulating Hormone (TSH) Levels Thyroid Stimulating Hormone (TSH) Levels Condition rs10814915 rs10814915 GLIS3

What the study found

Who was studied 119,715 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0517 SD lower (95% confidence interval 0.043-0.061); p = 1 × 10−29.

How common The C allele had a frequency of about 55% in the people studied.

Where it sits Chromosome 9, band 9p24.2 — in an intron of GLIS3.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thyroid stimulating hormone levels compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thyroid stimulating hormone levels.
T/T Published research associates this genotype with typical/baseline likelihood of Thyroid stimulating hormone levels — no copies of the reported risk allele.
Source
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
Zhou W, Brumpton B, Kabil O, Gudmundsson J, Thorleifsson G, Weinstock J, Zawistowski M, Nielsen JB, Chaker L, Medici M, Teumer A, Naitza S
and 44 more — show all
Sanna S, Schultheiss UT, Cappola A, Karjalainen J, Kurki M, Oneka M, Taylor P, Fritsche LG, Graham SE, Wolford BN, Overton W, Rasheed H, Haug EB, Gabrielsen ME, Skogholt AH, Surakka I, Davey Smith G, Pandit A, Roychowdhury T, Hornsby WE, Jonasson JG, Senter L, Liyanarachchi S, Ringel MD, Xu L, Kiemeney LA, He H, Netea-Maier RT, Mayordomo JI, Plantinga TS, Hrafnkelsson J, Hjartarson H, Sturgis EM, Palotie A, Daly M, Citterio CE, Arvan P, Brummett CM, Boehnke M, de la Chapelle A, Stefansson K, Hveem K, Willer CJ, Åsvold BO
Nature communications · 2020 · PMID 32769997 · open access

Questions about rs10814915

What is rs10814915?

rs10814915 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with thyroid stimulating hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10814915 linked to?

On MyGeneLog this position is linked to Thyroid Stimulating Hormone (TSH) Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs10814915 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10814915 come from?

GWAS Catalog, Nat Commun 2020, PMID:32769997. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Thyroid stimulating hormone levels (rs10814915). MyGeneLog™. https://www.mygenelog.com/variants/rs10814915

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