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Early onset colorectal cancer

CASC8 · rs10808556

Where this position leads

Condition: Colorectal Cancer

rs10808556 Condition: Colorectal Cancer Colorectal Cancer Condition rs10808556 rs10808556 CASC8

What the study found

Who was studied 6,176 European ancestry cases, 65,829 European ancestry controls.

The effect Each copy of the C allele carried 1.14 times the odds of Early onset colorectal cancer (95% confidence interval 1.08-1.19); p = 3 × 10−10.

How common The C allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 8, band 8q24.21 — in a non-coding transcript of CASC8.

What each result means

C/C Two copies of the version the research linked to Early onset colorectal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Early onset colorectal cancer. That is a smaller link than two copies.
T/T No copy of the version the research linked to Early onset colorectal cancer. This is the starting point the study compared everyone against.
Source
Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer
Laskar RS, Qu C, Huyghe JR, Harrison T, Hayes RB, Cao Y, Campbell PT, Steinfelder R, Talukdar FR, Brenner H, Ogino S, Brendt S
and 24 more — show all
Bishop DT, Buchanan DD, Chan AT, Cotterchio M, Gruber SB, Gsur A, van Guelpen B, Jenkins MA, Keku TO, Lynch BM, Le Marchand L, Martin RM, McCarthy K, Moreno V, Pearlman R, Song M, Tsilidis KK, Vodička P, Woods MO, Wu K, Hsu L, Gunter MJ, Peters U, Murphy N
Colorectal Transdisciplinary (CORECT) Study, the Colon Cancer Family Registry (CCFR), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
Annals of oncology : official journal of the European Society for Medical Oncology · 2024 · PMID 38408508 · open access

Questions about rs10808556

What is rs10808556?

rs10808556 is a single position in the genome, in or near the CASC8 gene. Published research associates it with early onset colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10808556 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs10808556 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10808556 come from?

GWAS Catalog, Annals of oncology : official journal of the European Society for Medical Oncology 2024, PMID:38408508. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Early onset colorectal cancer (rs10808556). MyGeneLog™. https://www.mygenelog.com/variants/rs10808556

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