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Who was studied 4,125 European ancestry cases, 20,464 European ancestry controls.
The effect
Each copy of the T allele carried 1.20 times the odds of Idiopathic pulmonary fibrosis (95% confidence interval 1.13-1.26); p = 6 × 10−11.
How common The T allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 8, band 8q24.12 — in an intron of DEPTOR.
What each result means
G/GNo copy of the version the research linked to Idiopathic pulmonary fibrosis. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Idiopathic pulmonary fibrosis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Idiopathic pulmonary fibrosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs10808505 is a single position in the genome, in or near the DEPTOR gene. Published research associates it with idiopathic pulmonary fibrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10808505 linked to?
On MyGeneLog this position is linked to Idiopathic Pulmonary Fibrosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs10808505 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10808505 come from?
GWAS Catalog, Thorax 2022, PMID:35688625. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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