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Ulcerative colitis

near FCGR2A · rs10800314

Where this position leads

Condition: Ulcerative Colitis

rs10800314 Condition: Ulcerative Colitis Ulcerative Colitis Condition rs10800314 rs10800314 near FCGR2A

What the study found

Who was studied 857 African American or Afro-Caribbean cases, 119,909 African American or Afro-Caribbean controls, 5,229 European ancestry cases, 442,102 European ancestry controls, 529 Hispanic or Latin American cases, 58,892 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 0.14 higher (95% confidence interval 0.098-0.182); p = 2 × 10−13.

How common The C allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 1, band 1q23.3 — between genes, 2.4 kb from FCGR2A.

What each result means

A/A No copy of the version the research linked to Ulcerative colitis. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Ulcerative colitis. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Ulcerative colitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10800314

What is rs10800314?

rs10800314 is a single position in the genome, in or near the near FCGR2A gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10800314 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs10800314 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10800314 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Ulcerative colitis (rs10800314). MyGeneLog™. https://www.mygenelog.com/variants/rs10800314

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