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Gout and other crystal arthrop (PheCode 274)

near U3 · rs10799945

Where this position leads

Condition: Gout

rs10799945 Condition: Gout Gout Condition rs10799945 rs10799945 near U3

What the study found

Who was studied 14,867 African American or Afro-Caribbean cases, 102,953 African American or Afro-Caribbean controls, 3,900 Hispanic or Latin American cases, 54,594 Hispanic or Latin American controls, 1,256 East Asian ancestry cases, 5,386 East Asian ancestry controls, 44,197 European ancestry cases, 393,782 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0458 lower (95% confidence interval 0.033-0.059); p = 3 × 10−11.

How common The T allele had a frequency of about 53% in the people studied.

Where it sits Chromosome 1, band 1q23.3 — between genes, 186.6 kb from U3.

What each result means

C/C No copy of the version the research linked to Gout and other crystal arthrop (PheCode 274). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Gout and other crystal arthrop (PheCode 274). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Gout and other crystal arthrop (PheCode 274). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs10799945

What is rs10799945?

rs10799945 is a single position in the genome, in or near the near U3 gene. Published research associates it with gout and other crystal arthrop (phecode 274). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10799945 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs10799945 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10799945 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gout and other crystal arthrop (PheCode 274) (rs10799945). MyGeneLog™. https://www.mygenelog.com/variants/rs10799945

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