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Brain structure

HMGA2 · rs10784502

What the study found

Who was studied 2,020 European ancestry neuropsychiatric disorder cases, 5,775 European ancestry controls; replicated in 599 European ancestry neuropsychiatric disorder cases, 11,915 European ancestry controls, 143 European ancestry and African American neuropsychiatric disorder cases, 94 European ancestry and African American controls, 605 Hispanic controls.

The effect Each copy of the C allele shifted the measure 9.01e+03 mm3 higher (95% confidence interval 6525.78-11487.64); p = 1 × 10−12.

How common The C allele had a frequency of about 49% in the people studied.

Where it sits Chromosome 12, band 12q14.3 — in an intron of HMGA2.

What each result means

C/C Two copies of the version the research linked to Brain structure. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Brain structure. That is a smaller link than two copies.
T/T No copy of the version the research linked to Brain structure. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10784502

What is rs10784502?

rs10784502 is a single position in the genome, in or near the HMGA2 gene. Published research associates it with brain structure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs10784502?

Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10784502 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10784502 come from?

GWAS Catalog, Nat Genet 2012, PMID:22504417. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Brain structure (rs10784502). MyGeneLog™. https://www.mygenelog.com/variants/rs10784502

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