Standard

Cortical surface area

FGF17 · rs1078363

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 35,657 White British ancestry individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 1 × 10⁻¹⁶.

How common The T allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 8, band 8p21.3 — in an intron of FGF17.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-08-09. ClinVar record 1293289 NM_003867.4(FGF17):c.357+68T>C

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Cortical surface area. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Cortical surface area. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Cortical surface area. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology

Shadrin AA, Kaufmann T, van der Meer D, Palmer CE, Makowski C, Loughnan R, Jernigan TL, Seibert TM, Hagler DJ, Smeland OB, Motazedi E, Chu Y

and 10 more — show all

Lin A, Cheng W, Hindley G, Thompson WK, Fan CC, Holland D, Westlye LT, Frei O, Andreassen OA, Dale AM

NeuroImage · 2021 · PMID 34560273

Questions about rs1078363

What is rs1078363?

rs1078363 is a single position in the genome, in or near the FGF17 gene. Published research associates it with cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1078363 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1078363 come from?

GWAS Catalog, NeuroImage 2021, PMID:34560273. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cortical surface area (rs1078363). MyGeneLog™. https://www.mygenelog.com/variants/rs1078363

← See all variants