0 2017237Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI7Microsoft · Copilot0Amazon2Apple3Others7Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 170,494 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0234 lower (95% confidence interval 0.016-0.03); p = 7 × 10−11.
How common The C allele had a frequency of about 43% in the people studied.
Where it sits Chromosome 9, band 9q34.3 — in an intron of INPP5E.
What ClinVar records
ClassificationBenign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-06-14.
ClinVar record 675037NM_019892.6(INPP5E):c.1034+120A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Monocyte percentage of white cells compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Monocyte percentage of white cells.
T/TPublished research associates this genotype with typical/baseline likelihood of Monocyte percentage of white cells — no copies of the reported risk allele.
rs10781543 is a single position in the genome, in or near the INPP5E gene. Published research associates it with monocyte percentage of white cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10781543 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs10781543 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10781543 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2017237Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI7Microsoft · Copilot0Amazon2Apple3Others7Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Monocyte percentage of white cells (rs10781543). MyGeneLog™. https://www.mygenelog.com/variants/rs10781543