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Total body bone mineral density

ATP2B1-AS1 · rs10777221

Where this position leads

Condition: Total Body Bone Mineral Density

What the study found

Who was studied 56,284 European ancestry individuals, up to 1,333 African American individuals, up to 9,328 admixed individuals.

The effect Each copy of the T allele shifted the measure 0.0373 lower; p = 1 × 10⁻¹⁰.

How common The T allele had a frequency of about 61% in the people studied.

Where it sits Chromosome 12, band 12q21.33 — in an intron of ATP2B1-AS1.

What each result means

C/C No copy of the version the research linked to Total body bone mineral density. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Total body bone mineral density. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Total body bone mineral density. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I

and 77 more — show all

Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F

American journal of human genetics · 2018 · PMID 29304378

Questions about rs10777221

What is rs10777221?

rs10777221 is a single position in the genome, in or near the ATP2B1-AS1 gene. Published research associates it with total body bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10777221 linked to?

On MyGeneLog this position is linked to Total Body Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

Does having rs10777221 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10777221 come from?

GWAS Catalog, American journal of human genetics 2018, PMID:29304378. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Total body bone mineral density (rs10777221). MyGeneLog™. https://www.mygenelog.com/variants/rs10777221

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